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The interest traces to a 2014 Nature paper showing that knocking down NNMT in fat and liver protected mice against diet-induced obesity, glucose intolerance, and fatty liver, partly by shifting adipose NAD+ and SAM levels [4]

While a two-year clinical trial using 300 mg per day did not show major changes in nerve function, shorter studies lasting 3 to 12 weeks found that higher doses, up to 600 mg daily, improved symptoms in people with diabetic neuropathy

5 This can have significantly detrimental effects on the nervous system, cell division, and other methylation processes

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Trivit-B (Vitamin B12) is necessary for normal hematopoiesis (promotes maturation of erythrocytes) and is involved in the processes of transmethylation, hydrogen transport, synthesis of methionine, nucleic acids, choline, creatine