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Clinical trial data and post-marketing surveillance have documented gastrointestinal complaints in a substantial proportion of patients, with nausea being the most frequent (reported in 1540% of patients depending on the specific agent and dose), followed by vomiting, diarrhoea, constipation, and dyspepsia

The Glycine at position 2 is substituted with Aib (U), and this modification provides significant protection against enzymatic degradation by DPP-4

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