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Semaglutide itself lowers blood glucose through multiple mechanisms, including enhanced insulin secretion and reduced glucagon release
Others may benefit from longer-term use
Across all clinical trials, the side effect profile was consistently described as indistinguishable from placebo
The development of an oral GLP-1RA represents a significant milestone in the management of T2D, providing an additional efficacious treatment option for patients
One of the most important breakthroughs was insulin, a peptide hormone discovered in the early 1920s and quickly used as a life-saving treatment for diabetes
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