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For instance, GLP-1 and Exendin-4 can act on the gonadal axis, involving the hypothalamic kiss-1 system, to influence reproductive efficiency in female rats [51]
Studies indicate that approximately 20-30% of patients experience nausea when starting treatment with GLP-1 agonists, especially during the initial titration period
The parameters measured were glucose tolerance, endogenous secretory patterns of the proglucagon-derived hormones GLP-1, glucagon, and glicentin, as well as insulin, proinsulin, C-peptide and the enzyme dipeptidyl peptidase-4 (DPP-4)
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If they're going on it in the short term and having all these side effects and having to go off, then they're kind of all over the place, maybe not being as well managed as if they were on one medication consistently that was working
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