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Importantly, both classes exhibit glucose-dependent mechanisms, meaning their effects diminish as blood glucose normalises, substantially reducing the risk of hypoglycaemia compared to sulphonylureas or insulin
Resources: Dr
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In active acromegaly, many observations show that due to the high GH levels, glucose levels tend to be elevated, which is accompanied by the well-known high insulin levels in untreated acromegaly patients [33,34]
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