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Model performance of efficacy was further assessed by applying the model derived from our self-report data in a sample of 642 people who had provided HealthKit EHR data but had not completed the GLP1 survey, and hence were not used in the construction of the model

This should be accounted for in research designs that include oral glucose tolerance tests or mixed meal tolerance tests, as retatrutides pharmacodynamic effects will blunt the glycemic response independent of changes in fasting glucose or insulin sensitivity