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It is a convention borrowed from semaglutide and tirzepatide practice for researchers with a documented history of gastrointestinal sensitivity to incretin agonists, particularly anyone who tolerated 0.25 mg semaglutide poorly or who needed antiemetic cover during a prior tirzepatide titration [3][4]

hence, healthcare professionals are looking for therapies that are effective for long-term weight management

Phase 1 results informed dose selection, safety monitoring protocols, and patient selection criteria for Phase 2 trials

GLP-1 medications work by mimicking the effects of the GLP-1 hormone, which is produced within the small intestine

Despite this some coaches and elite triathletes reported positive effects