Cobalamin C defect or deficiency is the most common inborn error of cobalamin metabolism, with an estimated prevalence of 1:200,000 births (06)
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its availability for NAD + synthesis can be partially controlled by modulation of purine nucleotide phosphorylase (PNP), which plays a role in purine salvage pathways where purine bases are recycled into nucleotides 24 and in metabolism of the NAD + precursor nicotinamide riboside (NR) 25
Zhang Y, Zhao C, Zhang H, Liu R, Wang S, Pu Y, Yin L (2021) Integrating transcriptomics and behavior tests reveals how the C
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