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This outcome is thought to be an effect of all medications that increase GLP-1, because of both an increase in SDF-1-alpha and capillary density due to increased hypoxia-inducible factor 1-alpha and vascular endothelial growth factor

Orforglipron won on both endpoints: A1C dropped 2.2% versus 1.4% with oral semaglutide, and weight loss was 9.2% versus 5.3%

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In addition, GLP-1RAs have the potential to preserve or improve pancreatic -cell function [33,34]

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