To me, this is an inconclusive result: it cannot confidently rule out benefit or harm
Wood JD, Alpers DH, Andrews PLR (1999) Fundamentals of neurogastroenterology
All of these work to lift, hydrate and refine skin tone, whilst also softening texture
The following drugs include an FDA boxed warning for thyroid C-cell tumors : Semaglutide-based GLP-1 drugs: Ozempic Wegovy Rybelsus Tirzepatide-based drugs: Mounjaro Zepbound Dulaglutide and Liraglutide based drugs: Trulicity (dulaglutide) Victoza (liraglutide) Saxenda (liraglutide) Rybelsus, Ozempic and Wegovy all carry the same boxed warning (2025), related to Semaglutide the main ingredient in those drugs, set forth below: WARNING: RISK OF THYROID C-CELL TUMORS In rodents, semaglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures
While both compounds reportedly exhibited improvements in the mice, SSRIs may induce a wide range of additional unintended impacts, while PE-22-28 peptide is hypothesized not to