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The extensive preclinical literature should not be conflated with established human clinical efficacy
The CBP lysine acetyltransferase is a well-recognized, direct NRF2 binding partner (Tonelli et al, 2018), contributing to NRF2 transcriptional activity at reporter genes (Katoh et al, 2001) and responsible for acetylating NRF2 itself (Sun et al, 2009)
This lack of approval and evidence can raise safety concerns
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Normally, intrinsic factor carries the vitamin B12 we get from food to special cells in your small intestine
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