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Weight loss with tirzepatide 15 mg was 11.2 kg compared to 5.7 kg with semaglutide, nearly double
Early, small trials suggested a beneficial effect of ALCAR with respect to cognitive decline (98-100), whereas later, larger trials found little-to-no effect compared to placebo (101-103)
Fiber supplements, particularly inulin and resistant starch, have the most direct and well-understood mechanism for supporting GLP-1 production through SCFA production in the gut
Eating before or immediately after injection wastes the peptide's primary mechanism
doi: 10.3389/fmicb.2021.622091 89
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