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Some clinicians add subcutaneous injection (abdominal site) for systemic effects alongside oral dosing
Cardiovascular Outcomes Following Ertugliflozin Treatment in Type 2 Diabetes Mellitus Participants with Vascular Disease (VERTIS-CV), which compared ertugliflozin with placebo showed non-inferiority in regards to its primary MACE outcome, as well as a 30% reduction in HHF [41]
The positive control (distilled water) and the negative control (saline solution) were also performed
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