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At each doubling, receptor occupancy increases significantly but not overwhelmingly
To assess the half maximal inhibitory concentration (IC50) of FOXO4-DRI on the serum limitation-induced senescent fibroblast and the non-senescent control fibroblast, the fibroblast viability in the 2% FBS induced senescent fibroblast and 10% FBS cultured non-senescent control fibroblast with increasing concentrations of FOXO4-DRI was detected, and the cell viability curves were showed in Supplementary Fig
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In view of the recent interest in GLP-1R agonism as a nonalcoholic fatty liver disease treatment, we evaluated liver histology after chronic treatment, showing greater steatosis resolution with exendin-phe1 (Fig
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