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The findings show remarkable growth in rigor, scope, and collaborationbut also reveal persistent gaps that must be addressed if evidence-based addiction treatments are to reach everyone who needs them

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Since glucocorticoids are known to mediate inhibition of NF-kB (beneficially modulated by certain antioxidants such as thiols), adjunctive therapy with an effective thiol donor (e.g., NAC or SAMe) and vitamin E may optimize control of inflammatory mediator release and cell response as compared to pure immunomodulatory treatment or therapy limited to antioxidants