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The three main populations that should avoid supplementation are: People who are pregnant or breastfeeding Currently, there isn't enough research to determine whether glutathione supplementation is appropriate for people who are pregnant or breastfeeding
That being said, different mechanisms may offer different side effect profiles, and its possible that future multi-agonists could yield improved tolerability profiles
IDF Diabetes Atlas, 10th ed
Aib also confers a second, equally important advantage: protease resistance
Duncan, Jessica, et al
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