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Greater severity of insulin resistance has been correlated with poorer treatment response
The observed proportions of participants achieving 3%, 5% or 10% body weight loss at 26 weeks were greater with all oral semaglutide doses than with sitagliptin 100 mg (Table 2)
TZT is chemically modified by lipidation to increase its stability and cellular uptake
However, enzyme supplements may cause their own gastrointestinal side effects that can overlap with GLP-1-related symptoms, and some formulations containing bromelain or papain may interact with anticoagulants
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