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GLP-1 medications are contraindicated during pregnancy
Current Topics in Medicinal Chemistry
In L-cells of the lower intestine and colon the proprotein convertase subtilisin/kexin type 1 (or PCSK1/PC1) cleaves after single or double basic amino acids to liberate glicentin (amino acids 21-89 in proglucagon), oxyntomodulin (amino acids 53-89 in proglucagon), GLP-1 (amino acids 92-128 in proglucagon), and GLP-2 (amino acids 146-178 in proglucagon) (see UniProt P01275)
Emily Cooper, Mark Wright, and Andrea Taylor are joined by Dr
For FDA-approved GLP-1 and incretin-based medications, out-of-pocket cost can vary by brand, dose, pharmacy, insurance coverage, savings-card eligibility, approved indication, and program structure
