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In Phase 2 trials, participants began on a low dose and were gradually escalated over several weeks to higher maintenance doses, up to 12 mg weekly

The procedures introduced in Step One are continued, and the treatment is tailored using one or more modules shown in Figure 4

More is not always better, and thoughtful protocol design often outperforms brute force approaches over time

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To simulate ethanol-induced damage, the team sprayed 80% ethanol onto the stomach lining during the endoscopy