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While both agents target different pathways, their combination has not been extensively studied and may increase side effect risks without proportional efficacy gains
Clinical trials of GLP-1RAs have primarily focused on patients with obesity or overweight, yet the effectiveness in the cardiovascular protection appears independent of baseline BMI range (265)
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Building a Sustainable Diet Around Semaglutide The goal of semaglutide therapy is establishing long-term habits, not permanent food elimination
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