However, whether p53 is a bona fide substrate of COP1 in vivo is still a topic of ongoing debate 25,26,27,31

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10.1530/JOE-12-0143 140 StrmerE
The dosing protocol is five injections per week into an area of subcutaneous fat, such as an arm, a thigh, or your belly
CagriSema submitted for FDA approval in December 2025 with expected approval in Q4 2026 or Q1 2027, meaning launch around mid-2027