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Ann Neurol 42:644654 Guo W, Vandoorne T, Steyaert J et al (2020) The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications
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The protective effect of SFN appears to be NRF2-dependent, as NRF2 deficiency exacerbated psoriasis-like symptoms, as well as the inflammatory response and abnormal proliferation of keratinocytes in the mice, and SFN had little therapeutic effect in the IMQ-modeled knockout mice
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