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A single administration of CRISPR/Cas9 lipid nanoparticles achieves robust and persistent in vivo genome editing
Malaguarnera M, Gargante MP, Cristaldi E, Colonna V, Messano M, Koverech A, et al
Rating the quality of evidence - inconsistency
A meta-analysis of 18 studies found meaningful, statistically significant reductions in body weight and BMI, especially at doses above 1 gram per day for more than 8 weeks
Colonic Insl5 and plasma INSL-5 levels are elevated during fasting in calorie-restricted mice and normalize upon refeeding (164)
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