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Patients with Fitzpatrick IV-VI skin should be monitored for potential irritation during initial use, particularly in combination with other actives, and formulations should be pH-controlled (pH 3.5 or lower for efficacy without excessive irritation)
Glucagon-Like Peptide-1 Receptor Agonists and Gastrointestinal Adverse Events: a Systematic Review and Meta-Analysis
In 2050% of cases, this syndrome is induced by a deletion in the NIPBL gene on chromosome 5 (locus 5p13) [386, 387]
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