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This timing pattern suggests the symptom may be related to rapid metabolic shifts or dehydration rather than a direct toxic effect of the medication on muscle tissue itself

Rodbard HW, Rosenstock J, Canani LH (2019) Oral Semaglutide Versus Empagliflozin in Patients with Type 2 Diabetes Uncontrolled on Metformin: The PIONEER 2 Trial

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Food and Drug Administration (FDA), this loss of control is a key indicator of opioid use disorder and requires medical intervention for recovery