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In the context of bariatric surgery, rats lacking melanocortin 4 receptors (MC4Rs), which are activated by the POMC-cleavage product alpha-MSH [157], are still responsive to VSG [158]
Because the data were de-identified, investigators could not confirm medication adherence or review individual charts
Mass spectrometry data confirming correct molecular identity offers additional verification
Gradually tapering the dose rather than stopping abruptly helps minimize withdrawal effects
Together, this powerful combination has gained interest in research focused on systemic recovery , gut-skin axis , and complex inflammatory conditions
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