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doi: 10.7554/eLife.28766 25

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Primary safety endpoint Study procedures were well-tolerated, with no notable acute procedural complications

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Each pen contains 4 fixed doses which are given as one dose injected subcutaneously (under the skin) once weekly

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Staying well-hydrated is not optional on this combination

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Conversely, if GLP-1-related blunting is selective to reward-related content, these compounds may normalize aberrant hyperreactivity in individuals with obesity or substance use disorders without reducing negative affective processing

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