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The minimum hold time is 30 seconds, but ideally, patients should aim for 5 to 15 minutes
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Clin Toxicol 48:613 Du X, Edelstein D, Obici S, Higham N, Zou MH, Brownlee M (2006) Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
Additionally, the medication's effects on gastric emptying and glucose metabolism may influence energy levels, particularly during the dose-escalation phase
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