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This concern is real but often overstated, particularly in people who are insulin sensitive or adapting to fat burning, and it becomes secondary to the muscle preservation imperative when semaglutide is involved
Values between 12% may be indeterminate
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This can be useful as a starting point, but it can also be misleading
Populations were propensity matched (1:1) on various demographic and risk factors to balance baseline cohorts, according to the groups paper on the work in American Journal of Ophthalmology
A GLP-1 RA with proven cardiovascular benefit is also recommended as an option in patients with T2D and chronic kidney disease (CKD) to mitigate the risk of cardiovascular events
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