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Diet-induced obese (DIO) male mice were given daily subcutaneous tirzepatide (50 g/kg) or vehicle for 14 days

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Signs of dehydration : reduced urination, dark urine, dizziness, dry mouth, or confusion

Due to the role played by GSH in regulating redox balance, some molecules involved in GSH metabolism, such as glutathione peroxidase 4 (GPX4), GCLC and the cystine transporter solute carrier family 7 member 11 (SLC7A11), have been reported to inhibit the ferroptosis of cancer cells 38,39,40,41,42,43,44

By week 10 sensory function improved in all of the experimental groups with grades on the 0-3 scale ranging from 2.6-3.0