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Clues your aches may be GLP-1-related or medication adjacent: Aches begin or get worse after starting or increasing your GLP-1 dose Aches happen throughout your entire body rather than localized to a specific joint or muscle Youve also been experiencing nausea or reduced appetite Youre not drinking as much water as you used to You recently became more physically active Red flags that require prompt medical attention: Severe or worsening abdominal pain, especially radiating to the back (which could indicate possible pancreatitis) Dark-colored urine combined with muscle pain and weakness