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It activates the tyrosine kinase activity of IGF-1 receptor (IGF-1R), induces downstream MAPK/ERK and PI3K/Akt pathways, promotes the expression of cell cycle proteins (Cyclin D1, E), and accelerates the transition of cells from G1 phase to Sphase
Peer review Peer review information Nature Reviews Endocrinology thanks the anonymous reviewers for their contribution to the peer review of this work
Collins R, Kantarjian HM, Kadia TM, Borthakur G, Konopleva M, Garcia-Manero G, Daver NG, Pemmaraju N, Jabbour E, Estrov Z, Ramachandran A, Paradela J, Pond B, Ravandi F, Vusirikala M, Patel PA, Levis MJ, Perl AE, Andreeff M , Cortes JE
Reduce Skin Ageing, Dark Spots, Wrinkles and Detoxify Your Skin