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Both sorafenib and sulfasalazine are FDA approved drugs that have been shown to induce ferroptosis and inhibit tumor growth, however, in addition to inhibiting SLC7A11, sorafenib acts as a multi-kinase inhibitor and sulfasalazine blocks prostaglandin production (136, 137)

It is important to distinguish between a mild, transient burning sensation lasting seconds to minuteswhich is generally benignand more concerning signs such as persistent pain, spreading redness, swelling, or warmth that might indicate infection or allergic reaction

Diabetes Obes Metab (2016) 18:4919

According to the clinical trials discussed earlier, about 14% of participants were classified as "non-responders," meaning they lost less than 5% of their starting weight over 68 weeks

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