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Our study, which included a larger and more diverse real-world population with a longer follow-up duration, demonstrated significant psychiatric risks

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As the main active chemical component of Panax notoginseng saponins, notoginsenoside R1 attenuated inflammation and oxidative stress, reduced lung dry-to-wet ratio, alleviated the lung tissue damage, and ameliorated arterial blood gas changes in acute hypobaric hypoxia-induced HAPE rats (6000 m, exposed to a ProOx-830 hypobaric hypoxic chamber for 48 h), and its mechanism of action may be that notoginsenoside R1 promoted the activation of the ERK1/2-P90rsk-BAD signaling pathway (Pei et al., 2023)

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