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These medications are based on modified human GLP-1 sequences, though their development was inspired by the proof-of-concept established through the exendin-4 discovery
doi:10.3390/ijms21030892 142
Alcohol is also best avoided as it is high in calories and sugar content, contributing to dehydration and making people reach for unhealthy foods to satisfy their cravings
doi: 10.1016/j.bcp.2018.07.027 73 LiNLiuB-WRenW-ZLiuJ-XLiS-NFuS-Pet al
Adding a DPP-4 inhibitor to a potent GLP-1 agonist like semaglutide or tirzepatide may provide minimal additional glucose control while raising the risk of side effects such as nausea, vomiting, and pancreatitis-related concerns
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