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(2008, October 8)

doi: 10.1186/s12984-024-01311-2, 71 NitscheM

Extrinsic Factors: Interaction Between Metabolic Pathways/Fluxes and Breast Cancer Metastasis Induced by Hypoxia, Oxidative Stress, Acidosis, and Tumor Microenvironment Hypoxia Hypoxia represents an important characteristic in the TME arising as a mismatch between cellular oxygen consumption and supply (245)

As an indicative example, without its own effect on normal blood pressure, it counteracts L-NAME hypertension as well as L-arginine hypotension (Sikiric et al., 1997a)