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Events of dysesthesia and urinary tract infections were generally mild to moderate, the majority resolved during treatment, and most participants continued taking retatrutide

The department emphasized that veterans should not attempt to self-medicate with GLP-1 medications or discontinue proven, existing alcohol use disorder treatments without first consulting their health care providers, given that the trial remains an experimental research study rather than an approved treatment protocol

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In addition, dual incretin agonists (e.g., GIP/GLP-1 co-agonists such as tirzepatide) have expanded this therapeutic space, while other long-acting or multi-agonist candidates remain investigational ( This review provides a structured overview of how GLP-1 RAs impact gut microbiota composition and function, drawing on recent human clinical studies and mechanistic animal models

At Safi Miran Denver, these treatments have become a real breakthrough for many patients who have long dreamed of a slimmer figure without strict diets or risky surgeries