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Treatment with Laevo (l)-carnitine reverses the mitochondrial function of human embryos
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It is considered to be the key mechanism of ROS-induced sperm damage and leads to Loss of sperm motility Abnormal sperm morphology Reduced capacity for oocyte penetration Infertility To protect sperm from damage, the body depends on powerful antioxidant enzymes in the body such as superoxide dismutase (SOD), catalase, and glutathione peroxidase/reductase (GPX/GRD)
J Biol Chem 282:1842736 Pineda-Molina E, Klatt P, Vazquez J, Marina A, Garcia DL (2001) Glutathionylation of the p50 subunit of NF-kappaB: a mechanism for redox-induced inhibition of DNA binding
In humans, this drug exhibits full activation of GLP-1 receptor while only partial activation of glucagon receptor [109]
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