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No guaranteed purity, sterility, or accurate dosing

Localized reactions have been reported in patients using liraglutide and dulaglutide [43,44,45,46], while generalized urticaria and systemic anaphylaxis have been associated with exenatide and tirzepatide [47,48,49,50,51]

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Additional cost pressures loom from potential tariffs on imported drugs, while biosimilar competition is a longer-term certaintysemaglutide patents are expected to expire in 203132, with tirzepatide protections extending into 2036 and beyond