References: FDA Mounjaro Approval, FDA Zepbound Approval Indications and Contraindications Approved Uses Type 2 diabetes mellitus (as an adjunct to diet and exercise) Chronic weight management in adults with BMI 30 kg/m, or 27 kg/m with at least one weight-related comorbidity Contraindications Personal or family history of medullary thyroid carcinoma (MTC) Multiple endocrine neoplasia syndrome type 2 (MEN 2) Hypersensitivity to tirzepatide or any component of the formulation Note: Tirzepatide is not indicated for use in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis
However, rapid weight loss may temporarily affect: Hormone levels : Fat tissue produces oestrogen, and substantial fat loss can alter sex hormone balance
Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women, European Heart Journal , SL Hazen et al
However, retatrutide also carries higher GI side effect rates at these doses
This injectable peptide stimulates natural growth hormone production to help you achieve your desired results