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As the increased longevity and pathogen resistance observed in glp-1 mutants has been attributed to the absence of the germline and not a specific function of the glp-1 gene [8], [20], one might expect other germline-deficient mutants to show a similar lifespan extension and pattern of broad-range resistance to pathogen infection

14,17 Pharmacists and clinicians should counsel patients on red-flag symptoms that require prompt evaluation, such as persistent or severe abdominal pain, intractable nausea or vomiting, abdominal distention, bloating lasting several days, or the presence of bloody stools