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In Finnish public-sector employees, risk doubled among women 50 years with 10 years of NSW (OR = 2.05, 95% CI 1.044.01) 308
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These diverse phenotypes demonstrate the essential role of endolysosomal zinc homeostasis in maintaining neuronal proteostasis, systemic metal balance and tissue integrity across multiple disease contexts
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these effects are dose-dependent and resolve with dose reduction
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