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During the council meeting, members pointed out attempts to use products whose safety and efficacy have not been established in children and pregnant women, which were identified through the Drug Utilization Review system
Bepirovirsen, developed by GlaxoSmithKline (GSK), is a 2-MOE-modified ASO that targets all HBV RNAs, promoting RNase H-mediated RNA degradation, reducing HBV replication, and inhibiting HBsAg production
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During a median follow-up of 5.4 (IQR 5.15.9) years, patients with a 1.5 mg/week subcutaneous injection of dulaglutide showed a lower incidence rate of the primary composite outcome including non-fatal myocardial infarction, non-fatal stroke, or death from cardiovascular causes ( HR = 0.88, 95% CI 0.790.99, P = 0.026) [62]
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