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In April 2026 the sponsor announced positive topline results from the Phase 3 SYNCHRONIZE-1 obesity trial, but those company-reported data await full peer-reviewed publication and are best treated as preliminary until then

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In in vitro cell experiments using 3T3L1 preadipocytes as a model, treatment with NNMTi significantly reduced preadipocyte differentiation efficiency and markedly downregulated the expression of adipocyte markers (such as PPAR and C/EBP) in a dosedependent manner

an investigational growth-hormone secretagogue that was never FDA-approved

The evidence does not show that supplying extra methionine, inositol and choline by injection to a patient who is not deficient produces weight loss on its own