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This hormonal action triggers several physiological responses: Appetite regulation : Saxenda acts on receptors in the hypothalamus (the brain's appetite control centre) to increase feelings of fullness and reduce hunger signals Delayed gastric emptying : The medication slows the rate at which food leaves the stomach, prolonging satiety after meals Insulin secretion : In the pancreas, Saxenda stimulates insulin release when blood glucose levels are elevated, whilst simultaneously suppressing glucagon (a hormone that raises blood sugar) Reduced food intake : Through these combined mechanisms, patients typically consume fewer calories, leading to gradual weight loss It is important to understand that Saxenda does not directly alter sex hormones such as oestrogen, progesterone, or testosterone, nor does it directly affect thyroid hormone secretion
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Some patients are naturally less responsive to incretin-based therapies, though this represents a minority of cases
Trulicity has been shown to reduce the risk of major cardiovascular events, making it a beneficial choice for patients with type 2 diabetes and cardiovascular risk factors
