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Indications: Huntington's Chorea (a hyperkinetic movement disorder) A drug of first choice for this condition Side Effects: Sedation Depression (suicidal tendencies) Parkinsonism symptoms Lacks the hypotensive & GI side effects of reserpine due to its selectivity for central VMAT2 Pharmacokinetics: * undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug Readily crosses the blood brain barrier & depletes cerebral monoamine stores
, those with a body mass index (BMI) of greater than 30
Patients undergoing treatment for smoking cessation have been observed to consume significantly less alcohol after 12 weeks of treatment with dulaglutide compared to those receiving a placebo, irrespective of their smoking status
Glutathione deficiency in Parkinsons disease: intranasal administration as a method of augmentation
Follow-up: Progress is reviewed, and sessions are scheduled accordingly Step 5
