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The GSTF8 gene was also induced by H 2 O 2 through the activation of MPK3/MPK6 kinases (Kovtun et al., 2000) the promoter of which contains an as-1 motif, which is implicated in response to oxidative stress (Garretn et al., 2002)
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In a meta-analysis of patients with acute relapse or first onset schizophrenia, levels of peripheral pro-inflammatory cytokines including IL-6, IL-1, and IFN- were significantly decreased after antipsychotic treatment compared to baseline.128 Those results are in line with previous studies reporting that both typical and atypical antipsychotics suppress microglial activation, thus inhibiting inflammatory mediators.129130131132133 Antipsychotics also enhance neurogenesis