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The tradeoff is a slightly smaller GH pulse per dose compared to GHRP-2
While there is no rigid cutoff, peptides are notably smaller than proteins, generally consisting of relatively short strings of amino acids that can form straight lines or more complex ring structures
The same 200 to 300 mcg dose can produce a GH pulse of 15 to 30 ng/mL when fasted or a blunted pulse of 3 to 8 ng/mL after a high-carbohydrate meal, based on what we know from analogous GHRP pharmacology [4]
Therefore, it is advised that patients asking the question Should I switch from semaglutide to tirzepatide? are aware and informed that research about the long-term effects of the drug is still ongoing
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