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Adults meeting the studys obesity criteria, who newly initiated tirzepatide or semaglutide, were identified and compared with matched individuals who started naltrexone-bupropion, phentermine, or phentermine-topiramate

Future research is needed to address the effects of TAM on cell proliferation and survival to better understand how TAM affects neurogenesis across the lifespan and in both sexes

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At 10 nmol/l Ex-4 inhibits IB-phosphorylation and prevents NF-B/p65 nuclear translocation, halving tumor necrosis factor alpha (TNF-) and IL-6 both intracellularly and in the medium [19], thereby attenuating pro-inflammatory signaling and enhancing hMSC viability under inflammatory conditions