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Subsequent work by Pickart and Margolina identified clusters of affected genes spanning DNA repair, antioxidant defense, ubiquitinproteasome activity, anti-inflammatory signaling, and tissue remodeling [2]
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4.4.2 Role of iron, -syn, and neuromelanin in mitochondrial metabolism and PD pathogenesis PD is a multifactorial disease influenced by both environmental and genetic risk factors (259)
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